Official was never released for the PlayStation Portable (PSP). While you might find files labeled "Resident Evil 4 ISO PSP" online, these are typically fan-made mods, video files designed to look like gameplay, or ports of the mobile version. Why RE4 is Not on PSP
💡 If the game crashes on startup, try changing the "ISO Video Mount" or "UMD ISO Mode" in the VSH menu (accessed by pressing Select on the home screen) to Sony NP9660 Go to product viewer dialog for this item. or M33 Driver . Better Alternatives for Portable RE4 resident evil 4 iso psp
If you want Resident Evil 4 on a handheld, consider these instead: Official was never released for the PlayStation Portable